MPTP-induced ventral mesencephalic cell loss in the cat. - Suppr | 超能文献

MPTP-induced ventral mesencephalic cell loss in the cat.

作者信息

Williams J L, Schneider J S

机构信息

Department of Neurology, Hahnemann University School of Medicine, Philadelphia, PA 19102.

出版信息

Neurosci Lett. 1989 Jul 3;101(3):258-62. doi: 10.1016/0304-3940(89)90542-9.

DOI:10.1016/0304-3940(89)90542-9

Abstract

Immunohistochemical analysis of tyrosine hydroxylase (TH)-containing neurons in the cat ventral mesencephalon revealed a marked loss of substantia nigra pars compacta neurons and moderate losses of TH-positive neurons in the ventral tegmental area, retrorubral or A8 region, and in the substantia nigra pars lateralis of cats treated with the neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The pattern and magnitude of cell loss in these ventral mesencephalic regions parallels that previously reported for the MPTP-treated monkey. These results further support the use of the cat as a model for studying the pathology to catecholaminergic neurons induced by MPTP.

摘要

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