Lawson W B, Jeste D V, Hanin I, Kopp U, Wyatt R J
Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37232.
Psychiatry Res. 1989 Jul;29(1):45-53. doi: 10.1016/0165-1781(89)90186-8.
We measured red blood cell (RBC) choline and plasma choline concentrations in 27 chronic schizophrenic inpatients and 23 normal controls. Both blood choline measures had a significant test-retest reliability in patients whose neuroleptic status remained unchanged over 1 month. RBC choline concentration was significantly lower in patients medicated with neuroleptics and cogentin. Patients with a low RBC choline and a low RBC/plasma choline ratio were on significantly higher doses of medication and had higher scores on the hostility/suspiciousness subscale of the Brief Psychiatric Rating Scale. RBC choline increased when neuroleptics were discontinued. Blood choline measures were also compared among medication-free schizophrenic patients, inpatients with other diagnoses, and normal controls. No significant differences were seen among these groups for any choline measure, although the schizophrenic patients showed greater variability. Medication-free schizophrenic patients with such clinical factors as tardive dyskinesia and abnormalities on computed tomography contributed to this variability. Age was positively correlated with plasma choline.
我们测量了27名慢性精神分裂症住院患者和23名正常对照者的红细胞（RBC）胆碱和血浆胆碱浓度。在1个月内抗精神病药物状态未改变的患者中，两种血液胆碱测量方法均具有显著的重测信度。服用抗精神病药物和安坦的患者红细胞胆碱浓度显著降低。红细胞胆碱水平低且红细胞/血浆胆碱比值低的患者服用的药物剂量显著更高，并且在简明精神病评定量表的敌意/怀疑分量表上得分更高。停用抗精神病药物后红细胞胆碱水平升高。还对未服用药物的精神分裂症患者、其他诊断的住院患者和正常对照者的血液胆碱测量值进行了比较。尽管精神分裂症患者的变异性更大，但在这些组中，任何胆碱测量值均未观察到显著差异。有迟发性运动障碍和计算机断层扫描异常等临床因素的未服用药物的精神分裂症患者导致了这种变异性。年龄与血浆胆碱呈正相关。
