选择性和非选择性β1受体阻断对离体大鼠肾脏肾素分泌的影响。
Effects of selective and non-selective beta 1-blockade on renin secretion in the isolated rat kidney.
作者信息
Haro J M, Vargas F, Castillo M A, García-Torres L, Acuña D
机构信息
Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Granada, Spain.
出版信息
Rev Esp Fisiol. 1989 Jun;45(2):195-8.
PMID:2570449
Abstract
The participation of beta 1-adrenoceptor on renin secretion was studied in perfused rat kidney. Administration of propranolol, inhibited the renin release mediated by isoproterenol. Likewise, metoprolol and practolol, showed a similar potency to propranolol in inhibiting isoproterenol-induced renin secretion. These results suggest that the for isoproterenol-induced renin release in rats is a beta 1-type adrenoceptor.
摘要
在灌注大鼠肾脏中研究了β1-肾上腺素能受体对肾素分泌的作用。给予普萘洛尔可抑制异丙肾上腺素介导的肾素释放。同样，美托洛尔和普拉洛尔在抑制异丙肾上腺素诱导的肾素分泌方面显示出与普萘洛尔相似的效力。这些结果表明，大鼠中异丙肾上腺素诱导的肾素释放是通过β1型肾上腺素能受体介导的。
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