微米级钛-沸石Na-A的新型合成方法及其银交换形式的细胞毒性活性
Novel synthesis method of micronized ti-zeolite na-a and cytotoxic activity of its silver exchanged form.
作者信息
Youssef H F, Hegazy W H, Abo-Almaged H H, El-Bassyouni G T
机构信息
Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt.
Department of Chemistry, Faculty of Science, Suez University, Suez 43533, Egypt.
出版信息
Bioinorg Chem Appl. 2015;2015:428121. doi: 10.1155/2015/428121. Epub 2015 Feb 3.
The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.
核壳法被用作制备微粉化钛-沸石Na-A的一种新型合成工艺，该工艺第一步是在酸性介质中用四氯化钛包覆埃及高岭土，并在700°C下煅烧。将制备的钛包覆偏高岭土在80°C低温下进行2小时的微波辐照。通过傅里叶变换红外光谱（FTIR）、X射线荧光光谱（XRF）、X射线衍射（XRD）、扫描电子显微镜（SEM）和能谱仪（EDS）元素分析对制备的微粉化含钛沸石-A（Ti-Z-A）进行表征。还制备并表征了银交换形式的Ti-Z-Ag。通过原子吸收光谱法测定交换到钛-沸石结构上的银的重量百分比（Wt%）。报道了Ti-Z-Ag对人肝癌细胞系（HePG2）、结肠癌细胞系（HCT116）、肺癌细胞系（A549）和人白种人乳腺腺癌（MCF7）的体外细胞毒性活性。结果很有前景，表明微粉化钛-沸石-A的银交换形式可作为新型抗肿瘤药物。
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