Dudakov Jarrod A, Hanash Alan M, van den Brink Marcel R M
Immunology Program and.
Annu Rev Immunol. 2015;33:747-85. doi: 10.1146/annurev-immunol-032414-112123. Epub 2015 Feb 11.
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas, and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.
白细胞介素-22(IL-22)是一种最近被描述的IL-10家族细胞因子,由辅助性T(Th)17细胞、γδT细胞、自然杀伤T细胞以及新发现的固有淋巴细胞(ILC)产生。自2000年被发现以来,关于IL-22生物学特性的认识迅速发展,并且已在包括肠道、肺、肝脏、肾脏、胸腺、胰腺和皮肤在内的众多组织中确定了IL-22的作用。IL-22主要作用于非造血上皮细胞和基质细胞,在这些细胞中它可以促进增殖并在组织再生中发挥作用。此外,IL-22在屏障表面调节宿主防御。然而,IL-22也与几种涉及炎症组织病理学的病症有关。在本综述中,我们评估了目前对这种细胞因子的认识,包括其对上皮细胞功能的生理和病理影响。