Wolk Kerstin, Sabat Robert
Interdisciplinary group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Campus Charité Mitte, Charitéplatz 1, D-10117 Berlin, Germany.
Cytokine Growth Factor Rev. 2006 Oct;17(5):367-80. doi: 10.1016/j.cytogfr.2006.09.001. Epub 2006 Oct 9.
Interleukin (IL)-22, discovered in 2000, is a member of the IL-10 family of cytokines. The major sources of IL-22 are activated T1- and NK-cells. IL-22 acts via a heterodimeric receptor complex consisting of IL-22R1 and IL-10R2. Neither resting nor activated immune cells express IL-22R1 or respond to IL-22. In contrast, tissue cells at outer body barriers, i.e. of the skin, kidney, and the digestive and respiratory systems are targets of this cytokine. IL-22 functions by promoting the anti-microbial defense, protecting against damage, and re-organizing non-immune tissues. Furthermore, IL-22 induces acute phase reactants. These findings indicate that IL-22 represents a novel type of immune mediator that, although produced by immune cells, regulates tissue protection and homeostasis.
白细胞介素（IL）-22于2000年被发现，是细胞因子IL-10家族的成员。IL-22的主要来源是活化的T1细胞和自然杀伤（NK）细胞。IL-22通过由IL-22R1和IL-10R2组成的异二聚体受体复合物发挥作用。静息或活化的免疫细胞均不表达IL-22R1，也不响应IL-22。相反，体表屏障处的组织细胞，即皮肤、肾脏以及消化和呼吸系统的组织细胞，是这种细胞因子的作用靶点。IL-22通过促进抗菌防御、防止损伤以及重组非免疫组织来发挥功能。此外，IL-22可诱导急性期反应物。这些发现表明，IL-22代表了一种新型免疫介质，尽管由免疫细胞产生，但却调节组织保护和内环境稳定。
