Hirata Y, Fukui K, Dan Y, Matsuoka H, Sugimoto T, Ishii M
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Eur J Clin Pharmacol. 1989;36(6):575-8. doi: 10.1007/BF00637738.
The renal and hormonal effects of the alpha 1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
