Oliveira Rafael Pires, Santiago Andrezza Fernanda, Ficker Sabine Madsen, Gomes-Santos Ana Cristina, Faria Ana Maria Caetano
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J Immunol Methods. 2015 Jun;421:36-43. doi: 10.1016/j.jim.2015.02.005. Epub 2015 Feb 20.
The ability to avoid inflammatory responses to dietary components and microbiota antigens in the gut mucosa is achieved by a mechanism termed oral tolerance. This phenomenon is crucial to maintain the physiological immune activity in the gut and to prevent inflammatory disorders such as food allergy and inflammatory bowel diseases. Moreover, orally administered antigens induce regulatory cells that control systemic inflammatory responses as well. Given its specific, systemic and long-lasting effects, oral tolerance represents a promising approach for immunotherapies that aim to modulate inflammatory and autoimmune diseases. However, there are different protocols of feeding for induction of oral tolerance, and they have an impact in tolerance efficiency and length. Herein, we present and discuss different experimental feeding protocols and how they influence the outcome of oral administration of antigens.
通过一种称为口服耐受的机制，可以避免肠道黏膜对饮食成分和微生物群抗原产生炎症反应。这种现象对于维持肠道中的生理免疫活性以及预防诸如食物过敏和炎症性肠病等炎症性疾病至关重要。此外，口服抗原还会诱导调节细胞，这些调节细胞也能控制全身炎症反应。鉴于其特异性、全身性和长效性，口服耐受是一种很有前景的免疫治疗方法，旨在调节炎症性和自身免疫性疾病。然而，诱导口服耐受有不同的喂养方案，它们会对耐受效率和持续时间产生影响。在此，我们展示并讨论不同的实验喂养方案以及它们如何影响口服抗原的结果。
