白细胞介素-1β对正常及免疫抑制小鼠全身性白色念珠菌感染的疗效。
Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice.
作者信息
Pecyk R A, Fraser-Smith E B, Matthews T R
机构信息
Syntex Research, Palo Alto, California 94304.
出版信息
Infect Immun. 1989 Oct;57(10):3257-8. doi: 10.1128/iai.57.10.3257-3258.1989.
Abstract
Prophylactic treatments with either recombinant human interleukin-1 beta (rHuIL-1 beta) or a muramyl dipeptide analog ([Abu1]MDP) enhanced the resistance of mice to systemic infection with Candida albicans. The optimum treatment regimen in both normal and cyclophosphamide-treated mice was intraperitoneal administration of 100 ng of rHuIL-1 beta or 1.6 mg of [Abu1]MDP per mouse once daily for 3 consecutive days before infection. Neither rHuIL-1 beta nor [Abu1]MDP was efficacious when started after the infection or when given before cyclophosphamide to mice infected subsequently. Continuing to treat after the infection with either drug neither enhanced nor antagonized the efficacy of prophylactic treatments.
摘要
用重组人白细胞介素-1β（rHuIL-1β）或一种胞壁酰二肽类似物（[Abu1]MDP）进行预防性治疗可增强小鼠对白色念珠菌全身感染的抵抗力。在正常小鼠和环磷酰胺处理的小鼠中，最佳治疗方案均为在感染前连续3天每天腹腔注射每只小鼠100 ng的rHuIL-1β或1.6 mg的[Abu1]MDP。在感染后开始治疗或在环磷酰胺给药前给予随后感染的小鼠时，rHuIL-1β和[Abu1]MDP均无效。感染后继续用这两种药物中的任何一种进行治疗既不会增强也不会拮抗预防性治疗的效果。
相似文献
1
Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice.白细胞介素-1β对正常及免疫抑制小鼠全身性白色念珠菌感染的疗效。
Infect Immun. 1989 Oct;57(10):3257-8. doi: 10.1128/iai.57.10.3257-3258.1989.
2
Relationship of Haemophilus influenzae type b pilus structure and adherence to human erythrocytes.b型流感嗜血杆菌菌毛结构与对人类红细胞黏附的关系。
Infect Immun. 1989 Oct;57(10):3259-60. doi: 10.1128/iai.57.10.3259-3260.1989.
3
Blocking of fimbria-mediated adherence of Haemophilus influenzae by sialyl gangliosides.唾液酸神经节苷脂对流感嗜血杆菌菌毛介导黏附的阻断作用。
Infect Immun. 1991 Dec;59(12):4473-7. doi: 10.1128/iai.59.12.4473-4477.1991.
4
Contribution of the major and minor subunits to fimbria-mediated adherence of Haemophilus influenzae to human epithelial cells and erythrocytes.主要和次要亚基对流感嗜血杆菌菌毛介导的与人上皮细胞和红细胞黏附的作用。
Infect Immun. 1995 Dec;63(12):4883-9. doi: 10.1128/iai.63.12.4883-4889.1995.
5
Comparison of hemagglutinating pili of type b and nontypeable Haemophilus influenzae.
J Infect Dis. 1992 Jun;165 Suppl 1:S105-6. doi: 10.1093/infdis/165-supplement_1-s105.
6
The erythrocyte and epithelial cell receptors for Haemophilus influenzae are expressed independently.流感嗜血杆菌的红细胞受体和上皮细胞受体是独立表达的。
Infect Immun. 1987 Oct;55(10):2355-8. doi: 10.1128/iai.55.10.2355-2358.1987.
7
Interaction of Haemophilus influenzae with human erythrocytes and oropharyngeal epithelial cells is mediated by a common fimbrial epitope.流感嗜血杆菌与人类红细胞和口咽上皮细胞的相互作用由一个共同的菌毛表位介导。
Infect Immun. 1988 Jul;56(7):1800-6. doi: 10.1128/iai.56.7.1800-1806.1988.
8
Surface structures and adherence properties of diverse strains of Haemophilus influenzae biogroup aegyptius.埃及嗜血杆菌生物群不同菌株的表面结构和黏附特性。
Infect Immun. 1991 Oct;59(10):3366-71. doi: 10.1128/iai.59.10.3366-3371.1991.
9
Combined inheritance of epithelial and erythrocyte receptors for Haemophilus influenzae.流感嗜血杆菌上皮细胞受体与红细胞受体的联合遗传
Infect Immun. 1990 Nov;58(11):3807-9. doi: 10.1128/iai.58.11.3807-3809.1990.
10
Role of pili in Haemophilus influenzae adherence and colonization.菌毛在流感嗜血杆菌黏附和定植中的作用。
Infect Immun. 1997 Aug;65(8):2997-3002. doi: 10.1128/iai.65.8.2997-3002.1997.
引用本文的文献
1
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.白细胞介素18可恢复半胱天冬酶1缺陷小鼠对白假丝酵母菌的缺陷性Th1免疫。
Infect Immun. 2000 Sep;68(9):5126-31. doi: 10.1128/IAI.68.9.5126-5131.2000.
2
Macrophages in resistance to candidiasis.巨噬细胞在抗念珠菌感染中的作用。
Microbiol Mol Biol Rev. 1997 Jun;61(2):170-92. doi: 10.1128/mmbr.61.2.170-192.1997.
3
A protective role of platelet-activating factor in murine candidiasis.血小板活化因子在小鼠念珠菌病中的保护作用。
Infect Immun. 1997 Apr;65(4):1321-6. doi: 10.1128/iai.65.4.1321-1326.1997.
4
Production and function of cytokines in natural and acquired immunity to Candida albicans infection.白色念珠菌感染天然免疫和获得性免疫中细胞因子的产生与功能
Microbiol Rev. 1995 Dec;59(4):646-72. doi: 10.1128/mr.59.4.646-672.1995.
5
Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1.粒细胞在重组白细胞介素-1诱导宿主对白色念珠菌抵抗力增强中的作用
Infect Immun. 1990 Oct;58(10):3319-24. doi: 10.1128/iai.58.10.3319-3324.1990.
6
Combined effect of fluconazole and recombinant human interleukin-1 on systemic candidiasis in neutropenic mice.氟康唑与重组人白细胞介素-1联合应用对中性粒细胞减少小鼠系统性念珠菌病的影响
Antimicrob Agents Chemother. 1992 Jun;36(6):1225-9. doi: 10.1128/AAC.36.6.1225.
7
Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice.正常及粒细胞减少小鼠白色念珠菌感染中的肿瘤坏死因子和白细胞介素-6
Infect Immun. 1992 Oct;60(10):4003-8. doi: 10.1128/iai.60.10.4003-4008.1992.
本文引用的文献
1
Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice.胞壁酰二肽类似物对小鼠铜绿假单胞菌或白色念珠菌感染的保护作用。
Infect Immun. 1981 Dec;34(3):676-83. doi: 10.1128/iai.34.3.676-683.1981.
2
Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia.针对长期发热且粒细胞减少的癌症患者的经验性抗生素和抗真菌治疗。
Am J Med. 1982 Jan;72(1):101-11. doi: 10.1016/0002-9343(82)90594-0.
3
Correlation between in vivo anti-Pseudomonas and anti-Candida activities and clearance of carbon by the reticuloendothelial system for various muramyl dipeptide analogs, using normal and immunosuppressed mice.使用正常和免疫抑制小鼠，研究各种胞壁酰二肽类似物的体内抗假单胞菌和抗念珠菌活性与网状内皮系统碳清除率之间的相关性。
Infect Immun. 1982 Jan;35(1):105-10. doi: 10.1128/iai.35.1.105-110.1982.
4
Two adjuvant-active muramyl dipeptide analogs induce differential production of lymphocyte-activating factor and a factor causing distress in guinea pigs.两种具有佐剂活性的胞壁酰二肽类似物可诱导豚鼠产生不同水平的淋巴细胞激活因子和一种引起不适的因子。
Infect Immun. 1984 May;44(2):344-50. doi: 10.1128/iai.44.2.344-350.1984.
5
Protective effect of a muramyl dipeptide analog encapsulated in or mixed with liposomes against Candida albicans infection.包裹于脂质体中或与脂质体混合的胞壁酰二肽类似物对白色念珠菌感染的保护作用。
Infect Immun. 1983 Jan;39(1):172-8. doi: 10.1128/iai.39.1.172-178.1983.
6
Late effects of chemotherapy on hematopoietic progenitor cells.化疗对造血祖细胞的晚期影响。
Exp Hematol. 1985;13 Suppl 16:49-56.
7
A cellular analysis of long-term haematopoietic damage in mice after repeated treatment with cyclophosphamide.环磷酰胺重复治疗后小鼠长期造血损伤的细胞分析
Cancer Chemother Pharmacol. 1986;18(1):11-6. doi: 10.1007/BF00253055.
8
Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-1a.重组人白细胞介素-1α诱导小鼠对细菌感染的抵抗力增强。
Infect Immun. 1987 Jun;55(6):1436-40. doi: 10.1128/iai.55.6.1436-1440.1987.
9
Anti-infectious activity of liposomal muramyl dipeptides in immunodeficient CBA/N mice.脂质体胞壁酰二肽在免疫缺陷CBA/N小鼠中的抗感染活性。
Infect Immun. 1987 Jun;55(6):1426-30. doi: 10.1128/iai.55.6.1426-1430.1987.
10
Interleukin 1 is a radioprotector.白细胞介素-1是一种辐射防护剂。
J Immunol. 1986 Apr 1;136(7):2483-5.
Zotero 插件