子痫前期女性胎盘组织中内皮型一氧化氮合酶、诱导型一氧化氮合酶及小窝主要蛋白质成分的表达
Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia.
作者信息
Smith-Jackson K, Hentschke M R, Poli-de-Figueiredo C E, Pinheiro da Costa B E, Kurlak L O, Broughton Pipkin F, Czajka A, Mistry H D
机构信息
Division of Women's Health, King's College London, Women's Health Academic Centre, UK; Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, UK.
Division of Women's Health, King's College London, Women's Health Academic Centre, UK; Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, UK; Laboratory of Nephrology - IPB, School of Medicine, PUCRS, Brazil.
出版信息
Placenta. 2015 May;36(5):607-10. doi: 10.1016/j.placenta.2015.02.001. Epub 2015 Feb 13.
Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.
小窝调节多种心血管功能，因此可能与先兆子痫相关，先兆子痫是一种特定于妊娠的疾病，其特征为高血压和蛋白尿。我们检测了正常血压对照组（n = 24）和先兆子痫妊娠组（n = 19）胎盘中小窝成分小窝蛋白1 - 3、窖蛋白1 - 4以及内皮型一氧化氮合酶/诱导型一氧化氮合酶的mRNA和蛋白表达/定位。先兆子痫患者胎盘中小窝蛋白-1、窖蛋白1 - 3的mRNA表达较低，而内皮型一氧化氮合酶表达增加（所有P < 0.05）。此外，先兆子痫患者小窝蛋白-1蛋白表达也降低（P = 0.007）；这可能是先兆子痫中的一种适应性反应，可能是为了减轻氧化应激/炎症。
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