Siddiqui O, Roberts M S, Polack A E
School of Pharmacy, University of Tasmania, Hobart, Australia.
J Pharm Pharmacol. 1989 Jun;41(6):430-2. doi: 10.1111/j.2042-7158.1989.tb06495.x.
The effect of iontophoresis on the rate of permeation of a number of therapeutically active weak acids and bases through excised human stratum corneum has been examined, over a range of pH values. It has been shown that the amount of ionized drug species present in the drug solution is an important factor in the delivery of acids and bases by this route and that the molecular weight of the drug does not influence the rate of delivery by iontophoresis.
在一系列pH值范围内，研究了离子导入对多种治疗活性弱酸和弱碱透过离体人角质层渗透速率的影响。结果表明，药物溶液中存在的离子化药物种类的量是通过该途径递送酸和碱的一个重要因素，并且药物的分子量不影响离子导入的递送速率。
