Fuller R W, Hemrick-Luecke S K
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285.
J Pharm Pharmacol. 1989 Jul;41(7):492-3. doi: 10.1111/j.2042-7158.1989.tb06509.x.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) at 90 mg kg-1 s.c., a dose lethal in non-pretreated mice, was well tolerated in selegiline [-)-deprenyl)-pretreated mice and produced persistent depletion of striatal dopamine and its metabolites one week after the last of four daily injections. The protective effect of selegiline against dopaminergic neurotoxicity of MPTP can thus be overridden by a high dose of MPTP that would be lethal without selegiline pretreatment.
1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP），腹腔注射剂量为90毫克/千克，该剂量对未预处理的小鼠具有致死性，但在司来吉兰（-）-去甲丙咪嗪）预处理的小鼠中耐受性良好，且在每日四次注射中的最后一次注射一周后，导致纹状体多巴胺及其代谢产物持续耗竭。因此，司来吉兰对MPTP多巴胺能神经毒性的保护作用可被高剂量的MPTP所抵消，若没有司来吉兰预处理，该高剂量MPTP将具有致死性。
