Ochoa-Hortal Rull M Á, Cano-García M C, Arrabal Martín M, Cano Gea R, Reyes García R, Arrabal-Polo M A
Servicio de Cirugía, Ortopedia y Traumatología, Hospital Rafael Méndez, Lorca, España.
UGC Urología Intercentros, Hospital La Inmaculada, Huércal Overa, España.
Actas Urol Esp. 2015 Jun;39(5):279-82. doi: 10.1016/j.acuro.2014.12.004. Epub 2015 Feb 20.
To demonstrate the attendance of mineral metabolism disorders and lithogenic factors in patients' urine with osteoporotic fracture without previously known stones
67 patients with osteoporotic fractures surgically treated in trauma service are included. The area of the fracture site, fracture mechanism and the presence of osteoporosis were the factors taken into account to diagnose osteoporotic fracture. Mineral metabolism, calciuria, oxaluria, uricosuria and citraturia in 24hours urine were analyzed. The presence of abnormal calcium and phosphorus metabolism was proved comparing hypercalciuria patients with normocalciuria ones.
12 men and 55 women with mean age 68.8±14.5 years old were included. Mean Body Mass Index (BMI) was 27.4±4.1kg/m2. 42% of patients showed hypercalciuria, 34% hyperoxaluria, 34% hypocitraturia and 7% hyperuricosuria. Statistically significant differences were observed only in fasting calcium/creatinine ratio (0.17 vs. 0.08; P<.0001) when comparing patients with hypercalciuria with those with normocalciuria.
Patients with osteoporotic fractures show different lithogenic factors in urine, mainly hypercalciuria, always in fasting conditions.
证明在既往无结石病史的骨质疏松性骨折患者尿液中存在矿物质代谢紊乱和致石因素
纳入67例在创伤科接受手术治疗的骨质疏松性骨折患者。骨折部位面积、骨折机制和骨质疏松的存在是诊断骨质疏松性骨折时考虑的因素。分析了24小时尿液中的矿物质代谢、尿钙、草酸尿、尿酸尿和枸橼酸尿。通过比较高钙尿症患者和正常钙尿症患者，证实了钙和磷代谢异常的存在。
纳入12名男性和55名女性，平均年龄68.8±14.5岁。平均体重指数（BMI）为27.4±4.1kg/m²。42%的患者表现为高钙尿症，34%为高草酸尿症，34%为低枸橼酸尿症，7%为高尿酸尿症。比较高钙尿症患者和正常钙尿症患者时，仅在空腹钙/肌酐比值上观察到统计学显著差异（0.17对0.08；P<.0001）。
骨质疏松性骨折患者尿液中存在不同的致石因素，主要是高钙尿症，且总是在空腹状态下。
