Gjavotchanoff Risto
Department of Laboratory Medicine, Bodenseelabor, Hörbranz, Austria ; Institute of Anatomy II, University of Jena, Jena University Hospital, Jena, Germany.
Int J Womens Health. 2015 Feb 9;7:205-11. doi: 10.2147/IJWH.S75288. eCollection 2015.
Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1), a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis.
子宫内膜异位症的诊断检查通常包括腹腔镜检查和活检组织学检查。迄今为止，在常规诊断评估中尚未有明确的该疾病实验室参数。在本研究中，我们检测了细胞角蛋白19（CYFRA 21-1）的尿液浓度，CYFRA 21-1是一种上皮特异性结构蛋白。我们对患有子宫内膜异位症的女性在整个月经周期的尿液样本进行了CYFRA 21-1免疫测定。我们观察到，与健康对照组相比，在卵泡晚期经肌酐水平校正后的CYFRA 21-1浓度显著升高。我们得出结论，尿液中CYFRA 21-1浓度的周期性升高可作为临床显性子宫内膜异位症诊断检查中有价值的非侵入性诊断参数。
