在子宫内膜异位症女性的尿液中发现一种新型生物标志物。
Discovery of a novel biomarker in the urine in women with endometriosis.
机构信息
Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, New South Wales, Australia.
出版信息
Fertil Steril. 2011 Jan;95(1):46-9. doi: 10.1016/j.fertnstert.2010.05.016. Epub 2010 Jun 18.
OBJECTIVE
To investigate whether proteins secreted in urine differ between women with and without endometriosis.
DESIGN
Laboratory study using human urine.
SETTING
University-based laboratory.
PATIENT(S): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage.
INTERVENTION(S): Urine collection from women with and without endometriosis.
MAIN OUTCOME MEASURE(S): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis.
RESULT(S): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis.
CONCLUSION(S): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
目的
探究子宫内膜异位症患者与非患者尿液中分泌蛋白是否存在差异。
设计
采用人体尿液进行实验室研究。
环境
以大学为基础的实验室。
患者
接受腹腔镜检查、宫腔镜检查和刮宫术的子宫内膜异位症患者与非患者。
干预
采集子宫内膜异位症患者与非患者的尿液。
主要观察指标
采用蛋白质组学技术和质谱分析法鉴定子宫内膜异位症患者与非患者尿液中分泌的蛋白。
结果
平均而言，133 种蛋白在子宫内膜异位症患者与非患者间存在显著差异。细胞角蛋白-19 在子宫内膜异位症患者尿液中高度上调。
结论
细胞角蛋白-19 可能是子宫内膜异位症有价值的尿液生物标志物。
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