Davidson G P, Whyte P B, Daniels E, Franklin K, Nunan H, McCloud P I, Moore A G, Moore D J
Gastroenterology Unit, Adelaide Medical Centre for Women and Children, South Australia.
Lancet. 1989 Sep 23;2(8665):709-12. doi: 10.1016/s0140-6736(89)90771-x.
The efficacy of a 10-day course of bovine colostrum with high antibody titre against the four known human rotavirus serotypes in protecting children against rotavirus infection was examined in patients admitted to hospital. Children aged 3 to 15 months were blocked in pairs according to ward accommodation (ie, isolation or open area). Each block contained 1 treated and 1 control child. The allocation to treatment or control (an artificial infant formula) was randomised. 9 of 65 control children but none of 55 treated children acquired rotavirus infection during the treatment period (p less than 0.001). The importance of protecting against rotavirus infection was highlighted by the fact that parents of symptomatic rotavirus-positive children sought medical attention seven times more often than did parents of symptomatic rotavirus-negative children (p less than 0.05).
在住院患者中，研究了一个疗程为10天、针对四种已知人类轮状病毒血清型具有高抗体滴度的牛初乳对预防儿童轮状病毒感染的疗效。3至15个月大的儿童根据病房住宿情况（即隔离区或开放区）配对分组。每组包含1名接受治疗的儿童和1名对照儿童。治疗组或对照组（一种人工婴儿配方奶粉）的分配是随机的。在治疗期间，65名对照儿童中有9名感染了轮状病毒，而55名接受治疗的儿童中无一感染（p<0.001）。有症状的轮状病毒阳性儿童的父母寻求医疗护理的频率比有症状的轮状病毒阴性儿童的父母高7倍，这一事实凸显了预防轮状病毒感染的重要性（p<0.05）。
