《美国国家癌症研究所杂志》与癌症预防
JNCI and cancer prevention.
作者信息
Dunn Barbara K, Ghosh Sharmistha, Kramer Barnett S
机构信息
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD (BKD, SG, BSK).
出版信息
J Natl Cancer Inst. 2015 Feb 24;107(3). doi: 10.1093/jnci/djv021. Print 2015 Mar.
The Journal of the National Cancer Institute (JNCI), with its broad coverage of bench research, epidemiologic studies, and clinical trials, has a long history of publishing practice-changing studies in cancer prevention and public health. These include studies of tobacco cessation, chemoprevention, and nutrition. The landmark Breast Cancer Prevention Trial (BCPT)-the first large trial to prove efficacy of a preventive medication for a major malignancy-was published in the Journal, as were key ancillary papers to the BCPT. Even when JNCI was not the publication venue for the main trial outcomes, conceptual and design discussions leading to the trial as well as critical follow-up analyses based on trial data from the Prostate Cancer Prevention Trial (PCPT) and the Selenium and Vitamin E Chemoprevention Trial (SELECT) were published in the Journal. The Journal has also published important evidence on very charged topics, such as the purported link between abortion and breast cancer risk. In summary, JNCI has been at the forefront of numerous major publications related to cancer prevention.
《国家癌症研究所杂志》（JNCI）广泛涵盖基础研究、流行病学研究和临床试验，在发表改变癌症预防和公共卫生实践的研究方面有着悠久的历史。这些研究包括戒烟、化学预防和营养方面的研究。具有里程碑意义的乳腺癌预防试验（BCPT）——首个证明预防性药物对一种主要恶性肿瘤有效的大型试验——发表在该杂志上，BCPT的关键辅助论文也是如此。即使JNCI不是主要试验结果的发表平台，导致该试验的概念和设计讨论以及基于前列腺癌预防试验（PCPT）和硒与维生素E化学预防试验（SELECT）的试验数据进行的关键后续分析也发表在该杂志上。该杂志还发表了关于极具争议性话题的重要证据，比如堕胎与乳腺癌风险之间所谓的联系。总之，JNCI一直处于众多与癌症预防相关的重大出版物的前沿。
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