Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blyth Boulevard, Charlotte, NC 28203, USA.
Int J Endocrinol. 2015;2015:685281. doi: 10.1155/2015/685281. Epub 2015 Feb 3.
Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum progesterone for both male and female partners were measured 10 hours after intercourse. One week later, subjects were crossed over to receive the opposite formulation. In the third week, women used progesterone gel at night and abstained from intercourse. Results. Serum progesterone was significantly reduced with vaginal progesterone gel + intercourse compared with vaginal progesterone gel + abstinence (P = 0.0075). Men absorbed significant progesterone during intercourse with a female partner using vaginal progesterone gel compared to placebo (P = 0.0008). Conclusion(s). Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support. Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido. This study is registered under Clinical Trial number NCT01959464.
目的。确定性行为是否会降低阴道用黄体酮凝胶在女性体内的吸收，并确定男性在性行为过程中是否会吸收黄体酮。研究设计。对 20 名育龄期女性及其男性性伴侣进行前瞻性、随机、交叉、对照研究，随机分配接受阴道用黄体酮凝胶（Crinone 8%凝胶，Actavis Inc.，美国）或安慰剂乳膏。性行为 10 小时后测量男性和女性伴侣的血清孕激素。一周后，受试者交叉接受相反的配方。在第三周，女性在晚上使用黄体酮凝胶并避免性行为。结果。与阴道用黄体酮凝胶+禁欲相比，阴道用黄体酮凝胶+性行为导致血清孕激素显著降低（P=0.0075）。与使用安慰剂的女性发生性行为时，男性吸收了大量的黄体酮（P=0.0008）。结论。女性在性行为后阴道用黄体酮凝胶减少，这可能会降低黄体期支持期间的药物疗效。因为男性在性行为过程中吸收少量的孕激素，这种暴露可能会导致性欲下降等不良反应。本研究已在临床试验编号 NCT01959464 下注册。
