• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A comparison of DNA-RFLP typing with serology and mixed lymphocyte reaction in the selection of matched unrelated bone marrow donors.

作者信息

Clay T M, Jones H P, Bidwell J L, Darke C, Harvey J, Bradley B A

机构信息

United Kingdom Transplant Service, Bristol.

出版信息

Bone Marrow Transplant. 1989 Sep;4(5):493-7.

PMID:2571377
Abstract

Eleven leukaemic patients and 43 potential unrelated marrow donors were typed serologically, tested in mixed lymphocyte reaction (MLR) and typed by restriction fragment length polymorphism (RFLP) analysis. RFLP typing data were compared with DR serology and MLR results. Eleven of the 54 individuals showed discrepancies between DR serology and RFLP DR assignment. RFLP DR/DQ mismatch always correlated with positive MLR, but RFLP identity was present in both MLR negative and MLR positive pairs. RFLP typing cannot reliably predict a negative MLR response, but we suggest that it should be used in the selection of unrelated marrow donors to exclude mismatched donors from testing in the MLR. This will facilitate donor searches by reducing the number of MLR performed.

摘要

相似文献

1
A comparison of DNA-RFLP typing with serology and mixed lymphocyte reaction in the selection of matched unrelated bone marrow donors.
Bone Marrow Transplant. 1989 Sep;4(5):493-7.
2
HLA-DR and DQ matching by DNA restriction fragment length polymorphism methods and the outcome of mixed lymphocyte reaction tests in unrelated bone marrow donor searches. The IMUST Study.通过DNA限制性片段长度多态性方法进行HLA - DR和DQ配型以及无关骨髓供体搜索中混合淋巴细胞反应试验的结果。IMUST研究。
Bone Marrow Transplant. 1992 Mar;9(3):161-6.
3
A comparison of serological, cellular and DNA-RFLP methods for HLA matching in the selection of related bone marrow donors.血清学、细胞和DNA-RFLP方法在相关骨髓供体选择中进行HLA配型的比较。
Bone Marrow Transplant. 1989 Jan;4(1):63-8.
4
Influence of HLA-DP mismatches on primary MLR responses in unrelated HLA-A, B, DR, DQ, Dw identical pairs in allogeneic bone marrow transplantation.HLA-DP错配在异基因骨髓移植中对不相关HLA-A、B、DR、DQ、Dw全相同配对的原发性混合淋巴细胞反应的影响。
Bone Marrow Transplant. 1990 Nov;6(5):337-40.
5
Identification of unrelated HLA-identical bone marrow donors: RFLP, oligotyping and PCR fingerprinting for HLA class II compared to MLC responses.无关的HLA匹配骨髓供者的鉴定：与混合淋巴细胞培养反应相比，HLAⅡ类的限制性片段长度多态性分析、寡核苷酸分型及PCR指纹分析
Bone Marrow Transplant. 1993;11 Suppl 1:24-7.
6
MHC class III polymorphisms in selection of donors for BMT.骨髓移植供体选择中的MHC Ⅲ类多态性
Bone Marrow Transplant. 1993 Jan;11(1):37-41.
7
The impact of T-cell depletion on the effects of HLA DR beta 1 and DQ beta allele matching in HLA serologically identical unrelated donor bone marrow transplantation.T细胞清除对HLA血清学匹配的无关供者骨髓移植中HLA DRβ1和DQβ等位基因匹配效果的影响。
Biol Blood Marrow Transplant. 1997 Jun;3(2):76-82.
8
Predictive value of HLA class II PCR typing for the outcome of mixed lymphocyte reaction.人类白细胞抗原II类PCR分型对混合淋巴细胞反应结果的预测价值
Folia Biol (Praha). 1998;44(4):137-41.
9
The incidence of DPB1 differences between serological and mixed lymphocyte culture matched unrelated individuals: implications for selection of bone marrow donors.血清学和混合淋巴细胞培养匹配的无关个体之间DPB1差异的发生率：对骨髓供体选择的影响。
Bone Marrow Transplant. 1992 Mar;9(3):157-60.
10
Selection of unrelated bone marrow donors: does the current procedure warrant complete MHC class II identity?无关骨髓供体的选择：当前程序是否需要完全的MHC II类匹配？
Beitr Infusionsther. 1992;30:320-3.

引用本文的文献

1
Selection of unrelated donors for bone marrow transplantation is improved by HLA class II genotyping with oligonucleotide hybridization.通过寡核苷酸杂交进行HLA II类基因分型可改善骨髓移植无关供体的选择。
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7121-5. doi: 10.1073/pnas.88.16.7121.