Sansom D M, Amin S N, Bidwell J L, Klouda P T, Bradley B A, Evison G, Goulding N J, Hall N D, Maddison P J
UK Transplant Service, Bristol.
Br J Rheumatol. 1989 Oct;28(5):374-8. doi: 10.1093/rheumatology/28.5.374.
Eighty-three patients with rheumatoid arthritis (RA) were investigated for HLA-DQ and DR locus restriction fragment length polymorphisms (RFLP). Of the 83 patients, 61 (73%) possessed the DR4 allele and within this group we have investigated the relative frequencies of two DQ beta gene variants of DQw3, DQw7 and DQw8, one of which we had previously found to be raised in Felty's syndrome. This analysis revealed a significantly higher frequency of DQw7 containing haplotypes in DR4 positive rheumatoid patients (64%) than in DR-matched healthy controls (42%). Furthermore, the distribution of DQw7 was biased towards those patients with greater disability indicated by the HAQ score, more systemic disease and higher titres of rheumatoid factor, suggesting that DQw7 may contribute to disease expression.
对83例类风湿性关节炎（RA）患者进行了HLA - DQ和DR基因座限制性片段长度多态性（RFLP）检测。在这83例患者中，61例（73%）携带DR4等位基因，在该组患者中，我们研究了DQw3、DQw7和DQw8这两种DQβ基因变体的相对频率，其中一种我们之前发现在费尔蒂综合征中频率升高。该分析显示，DR4阳性类风湿患者中含DQw7单倍型的频率（64%）显著高于DR匹配的健康对照（42%）。此外，DQw7的分布偏向于那些由健康评估问卷（HAQ）评分表明残疾程度更高、全身性疾病更多且类风湿因子滴度更高的患者，这表明DQw7可能与疾病表现有关。
