Van Hout Marie Claire, Hearne Evelyn
a Lecturer, Waterford Institute of Technology-Health , Sport and Exercise Science , Waterford , Ireland.
J Psychoactive Drugs. 2015 Jan-Mar;47(1):30-41. doi: 10.1080/02791072.2014.974002.
Methoxphenidine (MXP) was one of several NMDA antagonists marketed in 2013 to replace the recently controlled compound Methoxetamine (MXE). A steep rise in user interest was recorded, despite vendor cautioning of limited user feedback. The study presented a phenomenological analysis of MXP experiences amongst recreational drug users as posted on public Internet fora. Internet searches were carried out using specific key words; "methoxphenidine," "MXP" and in combination with "experience," "report," "forum," and "trip." Seven self-reported experiences and 28 thread discussions relating sole use of MXP were analyzed using the Empirical Phenomenological Psychological method. Five themes and 61 categories emerged. MXP is marketed as a legal replacement for MXE, diphenidine, and ketamine, with a dissociative and stimulant wave outcome often lasting for days. Harm reduction tactics, awareness of prior tolerance to dissociative and optimal settings for use are discussed. Acute side-effects relate to hypertension and seizures. Chronic long-term memory loss and limb numbness is reported. Sense of empowerment occurs in the afterglow experience. Internet drug fora fuel information exchange and informed consumerism of synthetic compounds, and offer viable mechanisms for pre- and post-purchase decision making and indigenous harm reduction. Continued surveillance of synthetic market entries and user trends is warranted.
甲氧苯丙胺（MXP）是2013年上市的几种N-甲基-D-天冬氨酸（NMDA）拮抗剂之一，用于替代近期受到管控的化合物甲氧基苯乙胺（MXE）。尽管供应商提醒用户反馈有限，但对其的用户兴趣仍急剧上升。该研究对在公共互联网论坛上发布的娱乐性吸毒者使用MXP的经历进行了现象学分析。使用特定关键词进行互联网搜索；“甲氧苯丙胺”、“MXP”以及与“经历”、“报告”、“论坛”和“旅程”组合。采用实证现象学心理学方法分析了7份自我报告的经历以及28个仅涉及使用MXP的主题讨论。出现了5个主题和61个类别。MXP作为MXE、二苯丙胺和氯胺酮的合法替代品进行销售，其分离性和刺激性效果通常会持续数天。讨论了减少伤害的策略、对分离性药物先前耐受性的认识以及使用的最佳环境。急性副作用与高血压和癫痫发作有关。有报告称存在慢性长期记忆丧失和肢体麻木。在余韵体验中会产生增强感。互联网毒品论坛促进了合成化合物的信息交流和明智消费，并为购买前和购买后的决策以及本土减少伤害提供了可行机制。有必要对合成毒品市场的新进入产品和用户趋势持续进行监测。
