Zaĭtseva Iu V, Popova A A, Khmel' I A
Genetika. 2014 Apr;50(4):373-91.
Bacteria are able to sense an increase in population density and can respond to it by coordinated regulation of the expression of certain sets of genes in the total population of bacteria. This specific mode of regulation is known as Quorum Sensing (QS). The QS systems include low-molecular-weight signaling molecules of different chemical natures and the regulatory proteins that interact with the signaling molecules. The QS systems are global regulators of bacterial gene expression. They play an important role in controlling metabolic processes in bacteria. This review describes QS systems in members of the bacterial family Enterobacteriaceae functioning with the involvement of various signaling molecules, including N-acyl-homoserine lactones, AI-2, AI-3, peptides, and indole. The differences of the QS system in these bacteria from those in other taxonomic groups of bacteria are discussed. Data on the role of different types of QS systems in the regulation of different cellular processes in bacteria, i.e., their virulence, the synthesis of enzymes and antibiotics, biofilm formation, apoptosis, etc. are presented.
细菌能够感知种群密度的增加，并通过对细菌总体中某些基因集的表达进行协调调控来做出反应。这种特定的调控模式被称为群体感应（QS）。群体感应系统包括具有不同化学性质的低分子量信号分子以及与信号分子相互作用的调控蛋白。群体感应系统是细菌基因表达的全局调控因子。它们在控制细菌的代谢过程中发挥着重要作用。本综述描述了肠杆菌科细菌成员中的群体感应系统，这些系统在各种信号分子的参与下起作用，包括N-酰基高丝氨酸内酯、AI-2、AI-3、肽和吲哚。讨论了这些细菌中的群体感应系统与其他细菌分类群中的群体感应系统的差异。还介绍了不同类型的群体感应系统在调节细菌不同细胞过程中的作用的数据，即它们的毒力、酶和抗生素的合成、生物膜形成、细胞凋亡等。
