Richter Magdalena, Trzeciak Tomasz, Owecki Maciej, Pucher Andrzej, Kaczmarczyk Jacek
Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznan, Poland.
Int Orthop. 2015 Jun;39(6):1211-7. doi: 10.1007/s00264-015-2707-9. Epub 2015 Feb 26.
Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.
骨关节炎（OA）是全球肌肉骨骼残疾的最常见原因之一。传统上，人们认为肥胖通过增加关节结构的机械负荷促进OA的发生和发展。然而，研究表明，脂肪组织衍生的细胞因子（脂肪细胞因子）可能是肥胖与OA之间的联系。此外，根据最近的研究结果，这些细胞因子的主要靶点不仅可能是关节软骨，滑膜、软骨下骨和髌下脂肪垫也可能参与降解过程。本文综述了关于脂肪细胞因子在膝关节软骨降解、骨赘形成、髌下脂肪垫改变和滑膜炎中作用的最新报道。
