Wyskida Magdalena, Wyskida Katarzyna, Olszanecka-Glinianowicz Magdalena, Maruniak-Chudek Iwona, Sikora Jerzy, Chudek Jerzy
Zakład Patofizjologii Katedry Patofizjologii Wydziału Lekarskiego w Katowicach Śląskiego Uniwersytetu Medycznego w Katowicach.
Zakład Promocji Zdrowia i Leczenia Otyłości Katedry Patofizjologii Wydziału Lekarskiego w Katowicach Śląskiego Uniwersytetu Medycznego w Katowicach.
Postepy Hig Med Dosw (Online). 2015 Feb 15;69:207-13. doi: 10.5604/17322693.1140336.
Hypertension is one of the most common cardiovascular diseases during pregnancy. Primary hyperaldosteronism (PHA) is the most frequent endocrinological, secondary cause of hypertension, rarely diagnosed in pregnant women. In the available literature about 50 cases of PHA in pregnant women have been described. PHA is often a cause of resistant hypertension. PHA can cause life-threatening complications both for the pregnant woman and the fetus. Diagnosis of PHA in pregnancy is difficult due to the antagonistic effect of progesterone on aldosterone, physiological increase of aldosterone release during gestation and frequent normokalaemic clinical course. Typical pharmacological treatment of PHA is limited due to the anti‑androgenic effect of spironolactone, lack of data concerning the safety of eplerenone and limited access to amiloride in Poland. Surgical treatment is a therapeutic option only in early pregnancy. This paper presents the current state of knowledge on diagnostic methods and treatment of PHA in pregnant women and a systematic review of cases described in the literature.
