Liu X-h, Liang X-z, Fang X, Zhang W-P
School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100, Haiquan Road, Fengxian District, Shanghai, 201418, China.
Int J Cosmet Sci. 2015 Aug;37(4):446-53. doi: 10.1111/ics.12216. Epub 2015 Mar 25.
Octylmethoxycinnamate (OMC)-loaded solid lipid nanoparticles (SLNs) were prepared by ultrasonic emulsification method. Effects of process variables and formulation composition were investigated on particle size and polydispersity index (PI), and the UV absorbance. Effect of OMC concentration on entrapment efficiency (EE) was also studied.
The optimal formulation was characterized and evaluated by environment emission scanning electron microscopy (ESEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). In addition, the degradations of OMC from SLNs and OMC conventional emulsion were compared.
The composition of optimal formulation was determined as 5% (w/w) of solid lipid, 7% (w/w) of emulsifier and 9% of loaded OMC, resulting in a particle size of 392.8 nm, and EE of 88.73%, LD of 38.05% under the preparation condition of 6 min of sonication, 400 W of sonication power. ESEM study showed spherical particles with smooth surface. DSC studies indicated OMC encapsulation within the nanoparticle matrix. The characteristic peaks for OMC-SLNs stood at 1710, 1604, 1513, 1465 and 830.3 cm(-1) . The degradation rate of OMC was decreased when using SLNs formulations compared to conventional emulsion.
Hence, the developed SLNs can be used as sunscreen carrier for improve the stability.
采用超声乳化法制备了负载桂皮酸盐（OMC）的固体脂质纳米粒（SLNs）。研究了工艺变量和配方组成对粒径、多分散指数（PI）以及紫外吸光度的影响。还研究了OMC浓度对包封率（EE）的影响。
通过环境发射扫描电子显微镜（ESEM）、差示扫描量热法（DSC）和傅里叶变换红外光谱（FT-IR）对最佳配方进行表征和评价。此外，比较了SLNs和OMC传统乳液中OMC的降解情况。
确定最佳配方组成为5%（w/w）的固体脂质、7%（w/w）的乳化剂和9%的负载OMC，在超声处理6分钟、超声功率400W的制备条件下，粒径为392.8nm，EE为88.73%，LD为38.05%。ESEM研究显示颗粒呈球形，表面光滑。DSC研究表明OMC被包裹在纳米颗粒基质中。OMC-SLNs的特征峰位于1710、1604、1513、1465和830.3cm-1处。与传统乳液相比，使用SLNs配方时OMC的降解速率降低。
因此，所制备的SLNs可作为防晒载体以提高稳定性。
