羟甲异丁肾上腺素（一种β1肾上腺素能受体部分激动剂）在轻至中度心力衰竭患者中的长期疗效。
Long-term efficacy of xamoterol (a beta 1-adrenoceptor partial agonist) in patients with mild to moderate heart failure.
作者信息
Sørensen E V, Faergeman O, Day M A, Snow H M
机构信息
Department of Internal Medicine and Cardiology, Arhus Amtssygehus, Denmark.
出版信息
Br J Clin Pharmacol. 1989;28 Suppl 1(Suppl 1):86S-88S. doi: 10.1111/j.1365-2125.1989.tb03583.x.
Abstract
This study was designed to assess the efficacy of xamoterol in 14 patients with mild to moderate heart failure over a period of 18 months. A beneficial effect on exercise capacity and a lowering of heart rate on exercise was sustained, and ejection fraction did not change, although some deterioration may be expected over this length of time in patients with heart failure. Xamoterol is safe and effective, and its benefits are maintained over at least 18 months.
摘要
本研究旨在评估14例轻至中度心力衰竭患者使用xamoterol 18个月的疗效。对运动能力有有益影响，运动时心率降低，且射血分数未改变，尽管心力衰竭患者在此时间段内可能会出现一些恶化。Xamoterol安全有效，其益处至少可维持18个月。
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N Engl J Med. 1981 Jul 23;305(4):185-90. doi: 10.1056/NEJM198107233050402.
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Xamoterol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use.Xamoterol。对其药效学、药代动力学特性及治疗用途的初步综述。
Drugs. 1988 Oct;36(4):455-74. doi: 10.2165/00003495-198836040-00004.
Zotero 插件