Ariff Ms, Zulmi W, Faisham Wi, Nor Azman Mz, Nawaz Ah
Department of Orthopaedics, Traumatology and Rehabilitation,International Islamic University Malaysia, Kuantan, Malaysia.
Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Kelantan.
Malays Orthop J. 2013 Mar;7(1):56-62. doi: 10.5704/MOJ.1303.018.
We reviewed the surgical treatment and outcomes of 13 patients with pelvic osteosarcoma treated in our centre in the past decade. The study sample included 9 males and 4 females with a mean age of 28.1 years. Four patients had ileal lesions, five had acetabulum lesions, one had a ischiopubis lesion, and three had involvement of the whole hemipelvis. Seven patients presented with distant metastases at diagnosis. Limb salvage was performed in 6 patients and amputation in 7. In 60% of cases in the limb salvage surgery group, we attempted wide resection with positive microscopic margin compared to only 16.7% in the amputation group. Local recurrence was higher in the limb salvage group. Overall survival was 18 months for mean follow up of 14.8 months. Median survival was 19 months in the limb salvage group compared to 9 months in amputation group. The outcome of surgical treatment of pelvic osteosarcoma remains poor despite advancements in musculoskeletal oncology treatment.
Pelvic osteosarcoma, limb salvage surgery, hemipelvectomy, margins, oncologic outcomes.
我们回顾了过去十年间在本中心接受治疗的13例骨盆骨肉瘤患者的手术治疗情况及预后。研究样本包括9名男性和4名女性，平均年龄为28.1岁。4例患者有髂骨病变，5例有髋臼病变，1例有坐骨耻骨病变，3例累及整个半骨盆。7例患者在诊断时出现远处转移。6例患者接受了保肢手术，7例接受了截肢手术。保肢手术组60%的病例我们尝试进行了显微镜下切缘阳性的广泛切除，而截肢组仅为16.7%。保肢组局部复发率更高。平均随访14.8个月，总体生存率为18个月。保肢组中位生存期为19个月，而截肢组为9个月。尽管肌肉骨骼肿瘤治疗取得了进展，但骨盆骨肉瘤的手术治疗效果仍然很差。
骨盆骨肉瘤；保肢手术；半骨盆切除术；切缘；肿瘤学预后
