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Na/K ATPase activity in rat myometrial cells in culture exhibited a Kapp of 0.93 mM for Rb+ and a Ki of 31 microM for ouabain with respect to Rb+. 2. 86Rb+ uptake was stimulated by serum and monensin but was not affected by the uterine relaxants isoproterenol and relaxin in 0.5-7.5 mM Rb+. Nonetheless, these relaxants elicited significant increases in 45Ca2+ efflux under similar conditions. 3. These data suggest that increased Na/Ca exchange resulting from a stimulation of Na/K ATPase is not involved in the mechanism of action of relaxin and isoproterenol in the uterus.

培养的大鼠子宫肌层细胞中钠钾ATP酶活性显示，相对于铷离子，铷离子的表观解离常数（Kapp）为0.93 mM，哇巴因对铷离子的抑制常数（Ki）为31 microM。2. 在0.5 - 7.5 mM铷离子浓度下，血清和莫能菌素刺激了86铷离子摄取，但子宫松弛剂异丙肾上腺素和松弛素对其无影响。然而，在类似条件下，这些松弛剂引起了45钙离子外流的显著增加。3. 这些数据表明，由钠钾ATP酶刺激导致的钠钙交换增加不参与松弛素和异丙肾上腺素在子宫中的作用机制。

Na/K ATPase activity in rat myometrial cells in culture exhibited a Kapp of 0.93 mM for Rb+ and a Ki of 31 microM for ouabain with respect to Rb+. 2. 86Rb+ uptake was stimulated by serum and monensin but was not affected by the uterine relaxants isoproterenol and relaxin in 0.5-7.5 mM Rb+. Nonetheless, these relaxants elicited significant increases in 45Ca2+ efflux under similar conditions. 3. These data suggest that increased Na/Ca exchange resulting from a stimulation of Na/K ATPase is not involved in the mechanism of action of relaxin and isoproterenol in the uterus.

培养的大鼠子宫肌层细胞中钠钾ATP酶活性显示，相对于铷离子，铷离子的表观解离常数（Kapp）为0.93 mM，哇巴因对铷离子的抑制常数（Ki）为31 microM。2. 在0.5 - 7.5 mM铷离子浓度下，血清和莫能菌素刺激了86铷离子摄取，但子宫松弛剂异丙肾上腺素和松弛素对其无影响。然而，在类似条件下，这些松弛剂引起了45钙离子外流的显著增加。3. 这些数据表明，由钠钾ATP酶刺激导致的钠钙交换增加不参与松弛素和异丙肾上腺素在子宫中的作用机制。

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