钯催化的氧化偶氮苯与醇的区域选择性C-H键酰化反应。
Palladium-catalyzed regio-selective oxidative C-H bond acylation of azoxybenzenes with alcohols.
作者信息
Hou Lekai, Chen Xiangxiang, Li Shuang, Cai Suxian, Zhao Yanxia, Sun Meng, Yang Xiao-Juan
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China.
出版信息
Org Biomol Chem. 2015 Apr 14;13(14):4160-4. doi: 10.1039/c5ob00089k. Epub 2015 Feb 27.
A palladium-catalyzed regio-selective acylation of C-H bonds of azoxybenzenes with alcohols was developed using tert-butyl hydroperoxide (TBHP) as an oxidant. Alcohol derivatives can act as effective acyl precursors in situ, which are less toxic, inexpensive, stable, and commercially available. These transformations proceeded smoothly and could tolerate a variety of functional groups.
以叔丁基过氧化氢（TBHP）为氧化剂，开发了一种钯催化的氧化偶氮苯C-H键与醇的区域选择性酰化反应。醇衍生物可原位作为有效的酰基前体，其毒性较小、价格低廉、稳定性好且可商购。这些转化反应进行顺利，并且能够耐受多种官能团。
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