干细胞与组织工程在骨科运动医学中的作用：当前证据与未来方向。

The role of stem cells and tissue engineering in orthopaedic sports medicine: current evidence and future directions.

作者信息

Hogan MaCalus V, Walker Garth N, Cui Liang Richard, Fu Freddie H, Huard Johnny

机构信息

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.

Stem Cell Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A..

出版信息

Arthroscopy. 2015 May;31(5):1017-21. doi: 10.1016/j.arthro.2014.11.033. Epub 2015 Feb 25.

DOI:10.1016/j.arthro.2014.11.033

PMID:25726331

Abstract

The use of stem cell therapies for the treatment of orthopaedic injuries continues to advance. The purpose of this review was to provide an update of the current role and future directions of stem cell strategies in sports medicine. The application of cell-based treatments in the sports medicine arena has expanded in recent years. Promising preclinical results have led to translation of these novel therapies into the clinical setting. Early well-designed comparative clinical studies have also shown positive outcomes. Despite significant advances in this arena, there remains a need for additional high-powered and well-designed clinical trials to confirm the safety and efficacy of treatment.

摘要

干细胞疗法在骨科损伤治疗中的应用不断发展。本综述的目的是更新干细胞策略在运动医学中的当前作用和未来方向。近年来，基于细胞的治疗方法在运动医学领域的应用有所扩展。有前景的临床前研究结果已促使这些新疗法转化为临床应用。早期精心设计的比较临床研究也显示出了积极的结果。尽管该领域取得了重大进展，但仍需要更多大规模且设计良好的临床试验来证实治疗的安全性和有效性。