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结膜地图状溃疡:单纯疱疹病毒感染的一个被忽视的体征。

Conjunctival geographic ulcer: an overlooked sign of herpes simplex virus infection.

作者信息

Hung Jia-Horung, Chu Chang-Yao, Lee Chaw-Ning, Hsu Chao-Kai, Lee Julia Yu-Yun, Wang Jen-Ren, Chang Kung-Chao, Huang Fu-Chin

机构信息

Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

出版信息

J Clin Virol. 2015 Mar;64:40-4. doi: 10.1016/j.jcv.2015.01.002. Epub 2015 Jan 5.

Abstract

Herpes simplex virus (HSV) ocular infection causes significant visual burden worldwide. Despite the fact that dendritic or geographic corneal ulcers are typical findings in HSV epithelial keratitis, conjunctival ulcer as a sign of HSV infection has rarely been reported. Although easily overlooked, this important sign could be enhanced by fluorescein staining. We report two cases of conjunctival geographic ulcers proven to be HSV infection by viral isolation and polymerase chain reaction (PCR). One patient had bilateral disease and blepharitis, and the other had unilateral involvement without skin lesions. With timely diagnosis and proper management, excellent visual outcome can be expected.

摘要

单纯疱疹病毒(HSV)眼部感染在全球范围内造成了严重的视觉负担。尽管树枝状或地图状角膜溃疡是HSV上皮性角膜炎的典型表现,但作为HSV感染体征的结膜溃疡却鲜有报道。虽然容易被忽视,但通过荧光素染色可使这一重要体征更加明显。我们报告了两例经病毒分离和聚合酶链反应(PCR)证实为HSV感染的结膜地图状溃疡病例。一例患者为双侧患病并伴有睑缘炎,另一例为单侧受累且无皮肤病变。通过及时诊断和恰当治疗,有望获得良好的视觉预后。

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