Henriksson P, Eriksson M, Ericsson S, Rudling M, Stege R, Berglund L, Angelin B
Department of Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
Lancet. 1989 Nov 18;2(8673):1178-80. doi: 10.1016/s0140-6736(89)91790-x.
To study the influence of tumour mass on lipid metabolism, the lipoprotein pattern in untreated patients with newly diagnosed cancer of the prostate was examined. Total cholesterol levels were reduced in patients with evidence of metastasis (n = 30) compared with those without metastasis (n = 73). Since the major fraction of serum cholesterol is contained in low-density lipoproteins (LDL), turnover of LDL was studied in detail in 8 patients compared with 12 age-matched healthy men. LDL were cleared faster in the 3 patients with metastatic disease than in the patients without metastasis and in controls, indicating faster catabolism of LDL. Thus in prostatic cancer an increased tumour burden is associated with increased elimination of LDL, which contributes to reduced serum cholesterol levels.
为研究肿瘤块对脂质代谢的影响，对未经治疗的新诊断前列腺癌患者的脂蛋白模式进行了检测。有转移证据的患者（n = 30）与无转移患者（n = 73）相比，总胆固醇水平降低。由于血清胆固醇的主要部分包含在低密度脂蛋白（LDL）中，对8例患者与12名年龄匹配的健康男性详细研究了LDL的周转情况。3例有转移性疾病的患者中LDL清除速度比无转移患者及对照组更快，表明LDL分解代谢更快。因此，在前列腺癌中，肿瘤负荷增加与LDL清除增加相关，这导致血清胆固醇水平降低。
