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美登木苷类天然产物及其四种新的二糖类似物的抗癌/抗菌活性构效关系研究

Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity.

作者信息

Bajaj Sumit O, Shi Pei, Beuning Penny J, O'Doherty George A

机构信息

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.

出版信息

Medchemcomm. 2014 Aug;5(8):1138-1142. doi: 10.1039/C4MD00095A.

DOI:10.1039/C4MD00095A
PMID:25729554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4338990/
Abstract

Ten members of the mezzettiaside family of natural products were synthesized and evaluated for anticancer and antibacterial activity. Complete anticancer (H460) and antibacterial () activities for the ten natural products and four new analogues were found. Comparison to the cleistrioside and cleistetroside classes of natural products were made.

摘要

合成了10种美泽蒂aside天然产物家族的成员，并对其抗癌和抗菌活性进行了评估。发现了这10种天然产物和4种新类似物的完整抗癌（H460）和抗菌活性。并与天然产物的克莱斯糖苷和克莱斯特特糖苷类进行了比较。

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本文引用的文献

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Chem Sci. 2014 Jun;5(6):2230-2234. doi: 10.1039/C4SC00593G.
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Structure Activity Relationship Study of the Cleistriosides and Cleistetrosides for Antibacterial/Anticancer Activity.用于抗菌/抗癌活性的闭花木苷和闭花木新苷的构效关系研究
ACS Med Chem Lett. 2012 Dec 13;3(12):1086-1090. doi: 10.1021/ml300303g. Epub 2012 Oct 30.
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Synthesis of several cleistrioside and cleistetroside natural products via a divergent de novo asymmetric approach.通过发散的从头不对称方法合成几种密穗岩黄芪苷和密穗岩黄芪苷天然产物。
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