FitzGerald P M, Jankovic J
Department of Neurology, Baylor College of Medicine, Houston, TX 77030
Neurology. 1989 Nov;39(11):1434-7. doi: 10.1212/wnl.39.11.1434.
Involuntary ocular deviations, or oculogyric crises (OGC), commonly occur in acute dystonic reactions to dopamine receptor blocking drugs (neuroleptics). We describe 4 patients with tardive OGC due to prolonged exposure to neuroleptics. In addition to the OGC, the patients had other tardive movement disorders. All patients improved with tetrabenazine. We conclude that tardive OGC are often not recognized and represent part of the spectrum of tardive dystonia.
非自主性眼球偏斜,即动眼危象(OGC),常见于多巴胺受体阻断药物(抗精神病药)引起的急性肌张力障碍反应。我们描述了4例因长期使用抗精神病药导致迟发性动眼危象的患者。除动眼危象外,这些患者还患有其他迟发性运动障碍。所有患者使用丁苯那嗪后病情均有改善。我们得出结论,迟发性动眼危象常常未被识别,是迟发性肌张力障碍谱系的一部分。