Bartke Andrzej, Kopchick John J
Division of Geriatrics Research (A.B.), Department of Medicine, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9628; and Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, and Edison Biotechnology Institute (J.J.K.), Ohio University, Athens, Ohio 45701.
Endocrinology. 2015 May;156(5):1620-2. doi: 10.1210/en.2015-1097. Epub 2015 Mar 2.
Studies of the effects of GH and the mechanisms of its actions frequently use rats or mice and various recombinant human GH preparations. Authors of many of these studies appear unaware of the fact that, in rodents, human GH signals through both GH and prolactin (PRL) receptors; thus, treatment with human GH is equivalent to a combined treatment with GH and PRL. GH receptors and PRL receptors are present in multiple cell types. Importantly, PRL exerts major effects on brain neuroendocrine action, female and male reproduction, metabolism, body composition, immune responses, and a host of other functions; thus, treatment of rodents with recombinant human GH could affect these important physiological parameters.
对生长激素（GH）的作用及其作用机制的研究经常使用大鼠或小鼠以及各种重组人生长激素制剂。许多此类研究的作者似乎并未意识到，在啮齿动物中，人生长激素通过生长激素受体和催乳素（PRL）受体发出信号；因此，用人生长激素进行治疗等同于用生长激素和催乳素联合治疗。生长激素受体和催乳素受体存在于多种细胞类型中。重要的是，催乳素对脑内神经内分泌作用、雌性和雄性生殖、代谢、身体组成、免疫反应以及许多其他功能发挥主要作用；因此，用重组人生长激素治疗啮齿动物可能会影响这些重要的生理参数。
