Yerbury R E, Cooper S J
School of Psychology, University of Birmingham, United Kingdom.
Pharmacol Biochem Behav. 1989 Jun;33(2):303-7. doi: 10.1016/0091-3057(89)90504-2.
The potent imidazopyridine hypnotic, zolpidem, binds to central benzodiazepine receptors and has predominantly sedative properties, as determine in animal models. In tests of palatable food consumption in nondeprived male rats, the present results indicate that zolpidem (0.3-3.0 mg/kg) had no effect on food intake. Its lack of effect contrasts sharply with other benzodiazepine agonists which strongly stimulate palatable food intake. Two other novel compounds, both of which bind to benzodiazepine receptors, and which have reduced propensity to induce sedative effects, increased palatable food consumption, although in differing ways. The imidazobenzodiazepine Ro23-0364 (0.3-10.0 mg/kg) dose-dependently increased feeding in the standard procedure, but failed to stimulate food intake in presatiated animals. The pyrazoloquinoline CGS 17867A (1.0-30.0 mg/kg) increased food intake in both test procedures, although the dose-effect relationship was nonmonotonic. Taken together, the data indicate a probable separation between hyperphagic and sedating effects of benzodiazepine receptor agonists. If zolpidem's sedative effect is linked to an action at a receptor subtype (benzodiazepine Type 1 or omega 1), then the hyperphagic effect of benzodiazepines may depend more on the alternative subtype.
强效咪唑并吡啶催眠药唑吡坦可与中枢苯二氮䓬受体结合，并且如在动物模型中所确定的那样，主要具有镇静特性。在未禁食雄性大鼠的可口食物消耗测试中，目前的结果表明唑吡坦（0.3 - 3.0毫克/千克）对食物摄入量没有影响。它缺乏这种作用与其他强烈刺激可口食物摄入的苯二氮䓬激动剂形成鲜明对比。另外两种新型化合物，它们都与苯二氮䓬受体结合，并且诱导镇静作用的倾向降低，但以不同方式增加了可口食物的消耗。咪唑并苯二氮䓬Ro23 - 0364（0.3 - 10.0毫克/千克）在标准程序中剂量依赖性地增加进食，但在预饱食动物中未能刺激食物摄入。吡唑并喹啉CGS 17867A（1.0 - 30.0毫克/千克）在两种测试程序中均增加了食物摄入量，尽管剂量 - 效应关系是非单调的。综合来看，数据表明苯二氮䓬受体激动剂的贪食和镇静作用可能是分离的。如果唑吡坦的镇静作用与受体亚型（苯二氮䓬1型或ω1型）的作用相关，那么苯二氮䓬的贪食作用可能更多地取决于另一种亚型。
