Qadir Muhammad Imran, Abbas Khizar, Tahir Madeha, Irfan Muhammad, Raza Bukhari Syeda Fiza, Ahmed Bilal, Hanif Muhammad, Rasul Akhtar, Ali Muhammad
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
College of Pharmacy, GC University, Faisalabad, Pakistan.
Pak J Pharm Sci. 2015 Mar;28(2):647-55.
Dengue fever is caused by the mosquito-borne dengue virus (DENV) serotypes 1-4, and is the most common arboviral infection of humans in subtropical and tropical regions of the world. Dengue virus infections can present with a spacious range of clinical signs, from a mild feverish illness to a life-threatening shock syndrome. Till now, there is no approved vaccine or drug against this virus. Therefore, there is an urgent need of development of alternative solutions for dengue. Several plant species have been reported with anti-dengue activity. Many herbal/natural drugs, most of which are commonly used as nutritional components, have been used as antiviral, larvicidal, mosquitocidal and mosquito repellents that may be used against dengue. The objective of this review article was to provide current approaches for the treatment and management/prevention of dengue fever by targeting viral proteins involved in replication cycle of the virus and different developmental stages of mosquito.
登革热由蚊媒传播的1-4型登革病毒（DENV）引起，是世界亚热带和热带地区人类最常见的虫媒病毒感染。登革病毒感染可表现出广泛的临床症状，从轻度发热疾病到危及生命的休克综合征。到目前为止，尚无针对该病毒的获批疫苗或药物。因此，迫切需要开发针对登革热的替代解决方案。已有几种植物被报道具有抗登革热活性。许多草药/天然药物，其中大多数通常用作营养成分，已被用作抗病毒、杀幼虫、灭蚊和驱蚊剂，可用于对抗登革热。这篇综述文章的目的是通过针对病毒复制周期中涉及的病毒蛋白以及蚊子的不同发育阶段，提供治疗和管理/预防登革热的当前方法。
