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Yawning induced by the selective dopamine D2 agonist N-0437 is blocked by the selective dopamine autoreceptor antagonist (+)-UH 232.

作者信息

Cooper S J, Rusk I N, Barber D J

机构信息

School of Psychology, University of Birmingham, United Kingdom.

出版信息

Physiol Behav. 1989 Jun;45(6):1263-6. doi: 10.1016/0031-9384(89)90119-4.

DOI:10.1016/0031-9384(89)90119-4
PMID:2573095
Abstract

Yawning and stretching responses were elicited in rats by a small dose (0.3 mg/kg) of the highly selective dopamine D2 agonist, N-0437. The responses were blocked by the highly selective dopamine autoreceptor antagonist, (+)-UH 232 (3.0 mg/kg), but not by raclopride at a dose which selectively blocks postsynaptic D2 receptors. The results strongly confirm the view that yawning and stretching are behavioral responses elicited by stimulation of presynaptic D2 receptors.

摘要

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Yawning induced by the selective dopamine D2 agonist N-0437 is blocked by the selective dopamine autoreceptor antagonist (+)-UH 232.
Physiol Behav. 1989 Jun;45(6):1263-6. doi: 10.1016/0031-9384(89)90119-4.
2
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Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin.2-（二正丙基氨基）四氢萘的（R）-和（S）-对映体的5-羟色胺能和多巴胺能活性差异
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8
(+)-UH 232 and (+)-UH 242: novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors.(+)-UH 232和(+)-UH 242：对自身受体具有优先作用的新型立体选择性多巴胺受体拮抗剂。
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10
5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.
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