Oyanagi Hidehito, Kameyama Hitoshi, Nogami Hitoshi, Shimada Yoshifumi, Nakano Mae, Nakano Masato, Ishikawa Takashi, Sakata Jun, Kobayashi Takashi, Minagawa Masahiro, Kosugi Shinichi, Koyama Yu, Wakai Toshifumi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
Gan To Kagaku Ryoho. 2014 Nov;41(12):1674-6.
A 69-year-old man with advanced rectal cancer and liver metastases was treated with 2 courses of chemotherapy with irinotecan and S-1 followed by low anterior resection and partial hepatectomy. Chemotherapy with S-1 was then administered for 22 months. However, lung metastases developed, for which partial pneumonectomy was performed. Seven months later, computed tomography (CT) revealed swelling of the left supraclavicular lymph node. Despite chemotherapy with 5- fluorouracil, Leucovorin, and oxaliplatin (mFOLFOX6); 5-fluorouracil, Leucovorin and irinotecan (FOLFIRI); and capecitabine plus bevacizumab, the lung metastases recurred and Virchow lymph node swelling was noted again. Accordingly, palliative therapy was administered. The patient died 3 years 1 month after Virchow lymph node resection. Herein, we describe a case of advanced rectal cancer, in which lung and Virchow lymph node metastases developed after liver metastasis. Surgical excision of the metastases resulted in long-term survival of 6 years following the first operation.
一名69岁患有晚期直肠癌并伴有肝转移的男性患者,接受了2个疗程的伊立替康和S-1化疗,随后进行了低位前切除术和部分肝切除术。之后给予S-1化疗22个月。然而,出现了肺转移,并进行了部分肺切除术。7个月后,计算机断层扫描(CT)显示左锁骨上淋巴结肿大。尽管接受了氟尿嘧啶、亚叶酸钙和奥沙利铂(mFOLFOX6);氟尿嘧啶、亚叶酸钙和伊立替康(FOLFIRI);以及卡培他滨加贝伐单抗化疗,但肺转移复发,且再次发现魏尔啸淋巴结肿大。因此,给予了姑息治疗。患者在魏尔啸淋巴结切除术后3年1个月死亡。在此,我们报告一例晚期直肠癌病例,该患者在肝转移后出现了肺和魏尔啸淋巴结转移。转移灶的手术切除使患者在首次手术后存活了6年。