Hojo Shigeyuki, Yoshioka Setsuko, Toyoda Yasuhiro, Kojima Fumiyoshi, Noma Toshiki, Miyagaki Hiromichi, Matsunaga Hiroki, Nishida Hisashi, Shingai Tatsushi, Fukunaga Hiroki, Fukuzaki Takayuki, Ohigashi Hiroaki, Maeura Yoshiichi
Dept. of Surgery, Osaka Saiseikai Senri Hospital.
Gan To Kagaku Ryoho. 2014 Nov;41(12):1909-11.
We report 2 cases of radiotherapy-induced sarcoma of the residual breast after breast cancer surgery. In 1 case, the patient was a 64-year-old woman. She underwent breast-conserving surgery and axillary lymph node dissection followed by irradiation to the residual breast in July 2001. A 1.1 × 1.0-cm tumor was noted in the residual breast 7 years 5 months after radiotherapy. An excisional biopsy was performed, and a histological diagnosis of angiosarcoma was made. She died of lung and peritoneal metastases 3 years 2 months after the diagnosis. In the other case, the patient was also 64 years old. She underwent breast-conserving surgery and sentinel lymph node biopsy followed by irradiation to the residual breast in October 2006. A 5.7 × 3.9-cm induration was noted in the residual breast 3 years 5 months after radiotherapy. A core needle biopsy was performed, and a histological diagnosis of sarcoma was made. Mastectomy was performed, and the histological diagnosis was malignant fibrous histiocytoma. She died of chest wall and intrapleural tumor recurrence 3 months after the mastectomy. Although radiotherapy-induced sarcoma is rare, early detection of the tumor in the irradiation area is important, as radiotherapy is often performed for breast cancer patients.
我们报告了2例乳腺癌手术后放疗诱发的残余乳腺肉瘤病例。其中1例患者为64岁女性。她于2001年7月接受了保乳手术和腋窝淋巴结清扫术，随后对残余乳腺进行了放疗。放疗7年5个月后，在残余乳腺中发现一个1.1×1.0厘米的肿瘤。进行了切除活检，组织学诊断为血管肉瘤。诊断后3年2个月，她死于肺和腹膜转移。另一例患者也是64岁。她于2006年10月接受了保乳手术和前哨淋巴结活检，随后对残余乳腺进行了放疗。放疗3年5个月后，在残余乳腺中发现一个5.7×3.9厘米的硬结。进行了粗针活检，组织学诊断为肉瘤。实施了乳房切除术，组织学诊断为恶性纤维组织细胞瘤。乳房切除术后3个月，她死于胸壁和胸膜内肿瘤复发。尽管放疗诱发的肉瘤很少见，但由于乳腺癌患者经常接受放疗，因此在放疗区域早期发现肿瘤很重要。
