[两例胰腺神经内分泌肿瘤伴多发肝转移采用可降解淀粉微球和奥曲肽治疗的病例]

[Two cases of neuroendocrine tumors of the pancreas with multiple liver metastases treated by use of degradable starch microspheres and octreotide].

作者信息

Goto Wataru, Shimizu Sadatoshi, Kotsuka Masaya, Sakae Masayuki, Kanazawa Akishige, Tsukamoto Tadashi, Yamashita Yoshito, Nishiguchi Yukio

机构信息

Dept. of Hepato-Biliary-Pancreatic Surgery and Gastroenterological Surgery, Osaka City General Hospital.

出版信息

Gan To Kagaku Ryoho. 2014 Nov;41(12):2139-41.

PMID:25731449

Abstract

The first case involved a 38-year-old man who received a pancreaticoduodenectomy and hepatectomy for a pancreatic neuroendocrine tumor (pNET) with multiple liver metastases. A recurrent tumor was detected in his liver 3 months after surgery. The second case involved a 61-year-old woman who received a distal pancreatectomy for a pNET. Multiple liver metastases were detected 29 months later. Both patients received a combined therapy consisting of trans-catheter arterial chemoembolization (TACE) with degradable starch microspheres (DSM) and octreotide. The combined therapy prolonged progression-free survival in both cases. Although only 2 cases were evaluated in this study, multimodal treatment consisting of TACE with DSM and octreotide effectively controlled liver metastasis of pNET in both cases.

摘要

第一例患者为一名38岁男性，因患有多发性肝转移的胰腺神经内分泌肿瘤（pNET）接受了胰十二指肠切除术和肝切除术。术后3个月，在其肝脏中检测到复发性肿瘤。第二例患者为一名61岁女性，因pNET接受了远端胰腺切除术。29个月后检测到多处肝转移。两名患者均接受了由可降解淀粉微球（DSM）经导管动脉化疗栓塞术（TACE）和奥曲肽组成的联合治疗。联合治疗使两例患者的无进展生存期延长。尽管本研究仅评估了2例患者，但由DSM联合TACE和奥曲肽组成的多模式治疗在两例患者中均有效控制了pNET的肝转移。