Division of Surgical Oncology, Department of Surgery, University of Tennessee Health Science Center, 910 Madison Avenue, Suite 208, Memphis, TN 38163, USA.
Surg Clin North Am. 2013 Jun;93(3):675-91. doi: 10.1016/j.suc.2013.02.001. Epub 2013 Apr 3.
Pancreatic neuroendocrine tumors account for 1% to 2% of pancreatic neoplasms and may occur sporadically or as part of a hereditary syndrome. Patients may present with symptoms related to hormone secretion by functional tumors or to locally advanced or metastatic nonfunctional tumors. Asymptomatic pancreatic neuroendocrine tumors are increasingly detected incidentally during abdominal imaging performed for other reasons. The management of localized pancreatic neuroendocrine tumors is surgical resection. Hepatic metastases are common and their management involves a variety of liver-directed therapies, which should be tailored according to extent of disease, symptoms, presence of extrahepatic metastases, and patient performance status.
胰腺神经内分泌肿瘤占胰腺肿瘤的 1%~2%，可散发发生，也可作为遗传性综合征的一部分。患者可能出现与功能性肿瘤激素分泌相关的症状，或出现局部晚期或转移性无功能性肿瘤的相关症状。在因其他原因进行腹部影像学检查时，越来越多地偶然发现无症状胰腺神经内分泌肿瘤。局限性胰腺神经内分泌肿瘤的治疗方法是手术切除。肝转移很常见，其治疗方法涉及多种针对肝脏的治疗方法，应根据疾病的范围、症状、是否存在肝外转移以及患者的体能状态来定制。
