Nakayama Akira, Tajima Hidehiro, Kitagawa Hirohisa, Shoji Masatoshi, Nakanuma Shinichi, Makino Isamu, Hayashi Hironori, Nakagawara Hisatoshi, Miyashita Tomoharu, Takamura Hiroyuki, Ohta Tetsuo
Dept. of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University.
Gan To Kagaku Ryoho. 2014 Nov;41(12):2205-7.
A 71-year-old female patient was administered 2 courses of neoadjuvant chemotherapy (GS therapy) for pancreatic body cancer, and underwent pancreatic body and tail resection. She was diagnosed as having T3N0M0, Stage III disease, and adjuvant chemotherapy with gemcitabine was started. However, a solitary 9 mm liver metastasis was found using CT imaging 3 months after the operation. We started hepatic arterial infusion chemotherapy (GEM+5-FU), with additional treatment using RFA after 5 courses, and a CR was achieved. The HAI regimens were changed to GEM+S-1 and a further 18 courses were administered. After HAI, adjuvant chemotherapy (S-1) was continued, but 2 further liver metastases were found. The patient was still alive 4 years after surgery and continued to undergo radiation chemotherapy.
一名71岁女性患者因胰体癌接受了2个疗程的新辅助化疗（GS方案），并接受了胰体尾切除术。她被诊断为T3N0M0，III期疾病，开始使用吉西他滨进行辅助化疗。然而，术后3个月通过CT成像发现了一个9毫米的孤立性肝转移灶。我们开始进行肝动脉灌注化疗（吉西他滨+5-氟尿嘧啶），5个疗程后加用射频消融治疗，达到了完全缓解（CR）。肝动脉灌注化疗方案改为吉西他滨+S-1，并再给予18个疗程。肝动脉灌注化疗后，继续进行辅助化疗（S-1），但又发现了2处肝转移。患者术后4年仍存活，继续接受放化疗。
