Takahashi Kazutaka, Harano Masao, Kato Takuya, Yoshida Kazuhiro, Sato Daisuke, Choda Yasuhiro, Tokumoto Noriaki, Kanazawa Takashi, Matsukawa Hiroyoshi, Ojima Yasutomo, Idani Hitoshi, Shiozaki Shigehiro, Okajima Masazumi, Ninomiya Motoki
Dept. of Surgery, Hiroshima City Hiroshima Citizens Hospital.
Gan To Kagaku Ryoho. 2014 Nov;41(12):2450-2.
A 53-year-old man presented with a continuous high fever and was diagnosed with diffuse large B-cell lymphoma with metastasis to the lung, spleen, and mesenterium. He was treated with cyclophosphamide and prednisolone followed by administration of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy 20 days later. Two days after initiation of CHOP therapy, the patient complained of severe abdominal pain. Perforative peritonitis was diagnosed using abdominal computed tomography. A perforation of the small intestine approximately 160 cm distal to the Treitz ligament was uncovered during emergency laparotomy. The risk of leakage was considered too high for anastomosis of the small intestine to be performed. Further, construction of an intestinal stoma could result in a high-output syndrome that could lead to difficulty in resuming chemotherapy. Based on these considerations, we fixed the anastomotic region to the abdominal wall using a technique similar to construction of an intestinal stoma. Post-operative anastomotic leakage did not occur. Nine days later, a perineal hernia was noted near the anastomotic site and a second operation was performed. The anastomotic site was placed back into the abdominal cavity during this operation. CHOP therapy was resumed 16 days after the first operation.
一名53岁男性因持续高热就诊,被诊断为弥漫性大B细胞淋巴瘤伴肺、脾和肠系膜转移。先给予环磷酰胺和泼尼松龙治疗,20天后给予环磷酰胺、阿霉素、长春新碱和泼尼松龙(CHOP)化疗。CHOP治疗开始两天后,患者主诉严重腹痛。通过腹部计算机断层扫描诊断为穿孔性腹膜炎。急诊剖腹手术时发现距屈氏韧带约160 cm处的小肠穿孔。由于小肠吻合口漏的风险过高,未进行小肠吻合。此外,构建肠造口可能导致高输出综合征,从而使化疗难以恢复。基于这些考虑,我们采用类似于构建肠造口的技术将吻合区域固定于腹壁。术后未发生吻合口漏。九天后,在吻合口附近发现会阴疝并进行了二次手术。此次手术中将吻合部位放回腹腔。首次手术后16天恢复CHOP治疗。