Ninomiya Riki, Mitsui Tetsuya, Komagome Masahiko, Satoh Shouichi, Ozawa Fumiaki, Beck Yoshifumi, Tamaru Junichi
Dept. of Hepato-Biliary-Pancreatic Surgery, Saitama Medical Center, Saitama Medical University.
Gan To Kagaku Ryoho. 2014 Nov;41(12):2515-7.
A 37-year-old woman presented with an asymptomatic pulmonary nodule. A pulmonary S8 segmentectomy was performed. Recurrence and metastasis were noted every 6 months after surgery; repeat surgeries were performed at 18, 24, and 36 months. On histopathological examination, the tumor showed spindle cell proliferation with infiltration of various inflammatory cells, and was diagnosed as inflammatory myofibroblastic tumor (IMT). An IMT is defined as a tumor of intermediate biological potential, which may sometimes metastasize. It is necessary to note the potential for metastasis in the future, especially in cases with anaplastic lymphoma kinase (ALK)-negative immunohistological staining, where the tumor grade can be high.
一名37岁女性因无症状肺结节就诊。行肺S8段切除术。术后每6个月进行复查,观察有无复发和转移;分别在术后18、24和36个月进行了再次手术。组织病理学检查显示肿瘤呈梭形细胞增生,伴有多种炎性细胞浸润,诊断为炎性肌纤维母细胞瘤(IMT)。IMT被定义为具有中等生物学潜能的肿瘤,有时可能发生转移。有必要注意其未来转移的可能性,尤其是在间变性淋巴瘤激酶(ALK)免疫组化染色阴性的病例中,此类肿瘤分级可能较高。