Dorman Charles J
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland.
J Mol Microbiol Biotechnol. 2014;24(5-6):316-31. doi: 10.1159/000368850. Epub 2015 Feb 17.
Nucleoid-associated proteins typically are abundant, low-molecular-mass polypeptides that bind DNA and alter its shape and its ability to participate in transactions such as transcription. Some can bind RNA and influence the gene expression profile of the cell at a posttranscriptional level. They also have the potential to model and remodel the structure of the nucleoid, contributing to chromosome packaging within the cell. Some nucleoid-associated proteins have been implicated in the facilitation of chromosome evolution through their ability to silence transcription, allowing new genes to be integrated into the nucleoid both physically and in a regulatory sense. The dynamic composition of the population of nucleoid-associated proteins in model bacteria such as Escherichia coli and Salmonella enterica links nucleoid structure and the global regulation of gene expression, enhancing microbial competitive fitness and survival in complex environments.
类核相关蛋白通常是丰富的低分子量多肽，它们结合DNA并改变其形状以及参与转录等过程的能力。有些蛋白可以结合RNA并在转录后水平影响细胞的基因表达谱。它们还具有塑造和重塑类核结构的潜力，有助于细胞内的染色体包装。一些类核相关蛋白通过其沉默转录的能力促进染色体进化，使新基因能够在物理和调控意义上整合到类核中。在诸如大肠杆菌和肠炎沙门氏菌等模式细菌中，类核相关蛋白群体的动态组成将类核结构与基因表达的全局调控联系起来，增强了微生物在复杂环境中的竞争适应性和生存能力。
