喀麦隆本土药用植物膜叶金丝桃中的抗菌和细胞毒性成分。

Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.

作者信息

Tala Michel Feussi, Talontsi Ferdinand Mouafo, Zeng Guang-Zhi, Wabo Hippolyte Kamdem, Tan Ning-Hua, Spiteller Michael, Tane Pierre

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.

Institute of Environmental Research (INFU) of the Faculty of Chemistry, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.

出版信息

Fitoterapia. 2015 Apr;102:149-55. doi: 10.1016/j.fitote.2015.02.006. Epub 2015 Feb 27.

DOI:10.1016/j.fitote.2015.02.006

PMID:25732351

Abstract

Bioassay guided fractionation of Hypericum riparium leaves extract has resulted in the isolation and characterization of three new compounds namely chipericumin E (1), hyperenone C (3), and hyperixanthone (5), together with twenty known compounds. Their structures were elucidated based on comprehensive interpretation of spectroscopic and spectrometric data. Compounds 1-4, and 6-8 displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxic effects on the human gastric cell line BGC-823 with IC50 values ranging from 6.54 to 18.50μM.

摘要

对湿生金丝桃叶提取物进行生物测定导向的分离，已分离并鉴定出三种新化合物，即湿生金丝桃素E（1）、金丝桃烯酮C（3）和湿生金丝桃酮（5），以及二十种已知化合物。基于对光谱和质谱数据的综合解释阐明了它们的结构。化合物1-4和6-8对耐甲氧西林金黄色葡萄球菌（MRSA）显示出中等抗菌活性，并对人胃癌细胞系BGC-823具有细胞毒性作用，IC50值范围为6.54至18.50μM。