Lagendijk Anne Karine, Hogan Benjamin M
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Curr Top Dev Biol. 2015;112:325-52. doi: 10.1016/bs.ctdb.2014.11.024. Epub 2015 Feb 11.
Blood and lymphatic vessels make up the vascular system of vertebrates and are lined by specialized endothelial cells. The connections between endothelial cells are formed by adhesion molecules and are essential to maintain cell-cell adhesion, cell-cell communication, and the integrity of our vascular tubes. One key adhesion molecule is the adherens junctional protein vascular endothelial cadherin (VE-cadherin). In addition to its role in endothelial adhesion, it is emerging that this protein is actively involved in modulating key cellular signaling cascades within endothelial cells and can control the behavior of endothelial cells during development and morphogenesis. We describe key studies that highlight VE-cadherin as a regulatory hub in endothelial cell signaling during angiogenesis, vessel morphogenesis, and vascular development.
血液和淋巴管构成了脊椎动物的血管系统，并由特化的内皮细胞排列而成。内皮细胞之间的连接由粘附分子形成，对于维持细胞间粘附、细胞间通讯以及血管管道的完整性至关重要。一种关键的粘附分子是粘附连接蛋白血管内皮钙粘蛋白（VE-钙粘蛋白）。除了在内皮细胞粘附中的作用外，越来越多的研究表明，这种蛋白质还积极参与调节内皮细胞内的关键细胞信号级联反应，并能在发育和形态发生过程中控制内皮细胞的行为。我们描述了一些关键研究，这些研究突出了VE-钙粘蛋白在血管生成、血管形态发生和血管发育过程中作为内皮细胞信号调节枢纽的作用。
