Sumigray Kaelyn D, Lechler Terry
Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.
Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.
Curr Top Dev Biol. 2015;112:383-414. doi: 10.1016/bs.ctdb.2014.11.027. Epub 2015 Feb 11.
Cell-cell adhesions are necessary for structural integrity and barrier formation of the epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of individual cell-cell junctions and their composite proteins in regulating epidermal development and function. In addition to individual adhesive functions, we will discuss emerging ideas on mechanosensation/transduction of junctions in the epidermis, noncanonical roles for adhesion proteins, and crosstalk/interdependencies between the junctional systems. These studies have revealed that cell adhesion proteins are connected to many aspects of tissue physiology including growth control, differentiation, and inflammation.
细胞间黏附对于表皮的结构完整性和屏障形成至关重要。在此，我们讨论遗传和细胞生物学研究所得出的见解，即单个细胞间连接及其复合蛋白在调节表皮发育和功能中的作用。除了各自的黏附功能外，我们还将讨论表皮中连接的机械传感/转导方面的新观点、黏附蛋白的非经典作用以及连接系统之间的相互作用/相互依赖性。这些研究表明，细胞黏附蛋白与组织生理学的许多方面相关联，包括生长控制、分化和炎症。
