Zaazaa Hala E, Elzanfaly Eman S, Soudi Aya T, Salem Maissa Y
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2015 May 15;143:251-5. doi: 10.1016/j.saa.2015.02.050. Epub 2015 Feb 19.
Ratio difference spectrophotometric method was developed for the determination of ibuprofen and famotidine in their mixture form. Ibuprofen and famotidine were determined in the presence of each other by the ratio difference spectrophotometric (RD) method where linearity was obtained from 50 to 600μg/mL and 2.5 to 25μg/mL for ibuprofen and famotidine, respectively. The suggested method was validated according to ICH guidelines and successfully applied for the analysis of ibuprofen and famotidine in their pharmaceutical dosage forms without interference from any additives or excipients.
建立了比率差示分光光度法用于测定布洛芬和法莫替丁的混合制剂。采用比率差示分光光度法（RD法）在彼此存在的情况下分别测定布洛芬和法莫替丁，布洛芬线性范围为50至600μg/mL，法莫替丁线性范围为2.5至25μg/mL。该方法按照国际协调会议（ICH）指南进行了验证，并成功应用于分析其药物剂型中的布洛芬和法莫替丁，不受任何添加剂或辅料的干扰。
